Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome
Annual rept. 30 Sep 2013-29 Sep 2014
VETERANS MEDICAL RESEARCH FOUNDATION (VETERANS AFFAIRS) SAN DIEGO CA
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The major goals and aims of this study are to investigate whether differences in cognitive outcome are related to mechanism of injury as well as white matter integrity using diffusion tensor imaging DTI. We are also collecting and analyzing data in order to determine whether MR variables of interest are associated with psychosocialclinical outcome, and whether there are group differences by mechanism of injury. Specifically, in the context of this study, we use novel, sophisticated MRI methods e.g., quantitative diffusion tensor DT tractography in order to characterize white matter changes seen within and across TBI subtypes, identify those at highest risk for poor outcomes, and gain knowledge about potential interventions to aid in recovery of brain functioning and cognition. In addition, we seek to identify the unique psychosocial challenges posed by differing mechanisms of injury as well as investigate the contribution of genetic factors Apolipoprotein-E -4 APOE 4 and brain-derived neurotrophic factor BDNF to brain integrity, neuropsychological functioning, and neurobehavioral outcome.
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