Accession Number:

ADA617037

Title:

Depleting Glycine and Sarcosine in Prostate Cancer Cells as a New Treatment for Advanced Prostate Cancer

Descriptive Note:

Final rept. 1 Feb 2014-31 Jan 2015

Corporate Author:

TULANE UNIV NEW ORLEANS LA ADMINISTRATORSOF THE TULANE EDUCATIONAL FUND

Personal Author(s):

Report Date:

2015-04-01

Pagination or Media Count:

198.0

Abstract:

Glycine is consumed b y rapidly proliferating cancer cells but not rapidly proliferating normal cells, which offers an opportunity to deplete glycine and inhibit cancer cells without affecting normal cells. The major source of intracellular glycine is a reversible conversion of serine through serine hydroxymethyltransferases SHMT. Glycine is required for synthesis of purines, proteins, glutathione, and sarcosine. Sarcosine is associated with invasion, migration, and metastasis of prostate cancer. Aminomethylphosphonic acid AMPA is an analog of glycine that can inhibit SHMT s enzyme activities, thus being able to block conversion of serine into glycine and subsequently to decrease sarcosine. We hypothesize that AMPA may inhibit proliferation, invasion, migration, and metastasis of prostate cancer through depleting glycine and sarcosine. In the one - year performance period, we found that AMPA indeed inhibited proliferation, invasion, migration, and metastasis of prostate cancer in the in vitro and in vivo experiment

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE