Accession Number:

ADA616972

Title:

Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

Descriptive Note:

Annual rept. 15 Aug 2013-14 Aug 2014

Corporate Author:

COPENHAGEN UNIV (DENMARK)

Personal Author(s):

• Salanti, Ali

Report Date:

2014-09-01

Pagination or Media Count:

16.0

Abstract:

In the past year of the project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSA interferes with key functions of the cancer cell like growth, migration and invasion.

Descriptors:

• *BREAST CANCER
• *GLYCOSIDASES
• *PROTEINS(CONJUGATED)
• *STEM CELLS
• BIOASSAY
• BIOPSY
• BLOOD CELLS
• CLINICAL MEDICINE
• ESCHERICHIA COLI
• IN VITRO ANALYSIS
• MALARIA
• MAMMARY GLANDS
• METASTASIS
• MUTATIONS
• ONCOLOGY
• PARASITOLOGY
• RECEPTOR SITES(PHYSIOLOGY)
• TISSUES(BIOLOGY)

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE