Accession Number:

ADA616584

Title:

Research in Prevention and Treatment of Noise-Induced Hearing Loss (NIHL)

Descriptive Note:

Annual rept. 1 Apr 2014-31 Mar 2015

Corporate Author:

SOUTHERN ILLINOIS UNIV SCHOOL OF MEDICINE SPRINGFIELD

Personal Author(s):

• Campbell, Kathleen

Report Date:

2015-04-01

Pagination or Media Count:

6.0

Abstract:

The current study will identify D-methionine D-met dose and delayed time otoprotective response from steady state and impulse noise-induced hearing loss NIHL. The third year was dedicated to completing data analysis from Year 2 and to further define maximum time delay for D-met post-noise rescue protection from permanent NIHL and to determine if additional D-met dosing for another 48 hours can improve post-noise rescue protection at the first rescue time with suboptimal protection. Groups of Chinchillas laniger n 10 received five intraperitoneal D-met 200 mgkgdose every 12 hours beginning 28 or 32 hours after steady state or impulse. D-met otoprotection was assessed by auditory brainstem response ABR analysis and outer hair cell OHC quantification. ABR analyses identified 28 hour rescue as the first sub-optimal rescue dose time. Additional D-met administration at 28 hour rescue significantly recovered the lost protection in steady state noise-exposed animals. Histological cytocochleogram analysis is still in progress to confirm electrophysiological assessment.

Descriptors:

• *AUDITORY DEFECTS
• *HEARING
• AUDITORY NERVE
• DATA PROCESSING
• DELAY
• ELECTROPHYSIOLOGY
• PREVENTION
• PROTECTION
• PULSES
• RESPONSE(BIOLOGY)
• STEADY STATE
• TIME INTERVALS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE