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Research in Prevention and Treatment of Noise-Induced Hearing Loss (NIHL)
Annual rept. 1 Apr 2014-31 Mar 2015
SOUTHERN ILLINOIS UNIV SCHOOL OF MEDICINE SPRINGFIELD
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The current study will identify D-methionine D-met dose and delayed time otoprotective response from steady state and impulse noise-induced hearing loss NIHL. The third year was dedicated to completing data analysis from Year 2 and to further define maximum time delay for D-met post-noise rescue protection from permanent NIHL and to determine if additional D-met dosing for another 48 hours can improve post-noise rescue protection at the first rescue time with suboptimal protection. Groups of Chinchillas laniger n 10 received five intraperitoneal D-met 200 mgkgdose every 12 hours beginning 28 or 32 hours after steady state or impulse. D-met otoprotection was assessed by auditory brainstem response ABR analysis and outer hair cell OHC quantification. ABR analyses identified 28 hour rescue as the first sub-optimal rescue dose time. Additional D-met administration at 28 hour rescue significantly recovered the lost protection in steady state noise-exposed animals. Histological cytocochleogram analysis is still in progress to confirm electrophysiological assessment.
APPROVED FOR PUBLIC RELEASE