Accession Number:

ADA616319

Title:

Self-Assembly of Large-Scale Shape-Controlled DNA Nano-Structures

Descriptive Note:

Final rept. 1 Aug 2011-31 Jul 2014

Corporate Author:

PRESIDENT AND FELLOWS OF HARVARD COLL CAMBRIDGE MA OFFICE OF SPONSORED RESEARCH

Personal Author(s):

Report Date:

2014-12-16

Pagination or Media Count:

112.0

Abstract:

We proposed to develop a methodology by using short synthetic DNA strands to build complex DNA nano-structures. In such a methodology, each short synthetic DNA strand, called DNA brick, is designed as a modular building block to assemble large structure with nanometer scale geometry control. We are using the methodology to build a variety of complex nano-structures, including 1D, 2D, 3D discrete structures and extended crystals. We are also developing a number of real world applications based on these novel structures. The successful development of this modular nano construction methodology and the associated real world applications will have transformative impact.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE