Accession Number:

ADA616121

Title:

Hydroxocobalamin Versus Sodium Thiosulfate for the Treatment of Acute Cyanide Toxicity in a Swine (Sus scrofa) Model

Descriptive Note:

Journal article

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Personal Author(s):

• Bebarta, Vikhyat S.
• Pitotti, Rebecca L.
• Dixon, Patricia
• Lairet, Julio R.
• Bush, Anneke
• Tanen, David A.

Report Date:

2012-06-01

Pagination or Media Count:

9.0

Abstract:

Study Objective We compare the efficacy of hydroxocobalamin to sodium thiosulfate to reverse the depressive effects on mean arterial pressure in a swine model of acute cyanide toxicity and gain a better understanding of the mechanism of action of the hydroxocobalamin in reversal of the toxicity.

Descriptors:

• *CARDIAC ARREST
• *CYANIDES
• *TACHYCARDIA
• *TOXICITY
• BLOOD PRESSURE
• GAIN
• HYPOTENSION
• MODELS
• REPRINTS
• SODIUM COMPOUNDS
• SWINE
• THIOSULFATES

Subject Categories:

• Medicine and Medical Research
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE