The Parkinson's Registry Investigation of Diagnosis and Etiology (PRIDE) Study
Annual rept. 15 Jul 2014-31 Mar 2015
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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Exposure to pesticides, solvents or traumatic brain injury increase PD risk. This study takes advantage of the population-based PD registry in Santa Clara County, California and extensive state toxicants databases to investigate the causes of PD and PD-related morbidity and mortality. Study Design Phase 1 The residence history of more than 3,000 PD cases from the population-based PD registry will be linked to geographically-specific exposure information to determine the relationship between toxicant exposure and PD incidence, morbidity and mortality using Cox proportional hazards regression with time-varying measures of chronic exposure, adjusting for confounding. Phase 2 Conduct a case-control study in a stratified random sample of cases and matched controls, collecting information on occupation, traumatic brain injury, and lifestyle risk factor information and conducting exams. Relevance This work can help identify the causes and, ultimately, ways to prevent PD.
- Medicine and Medical Research