Comparisons of Lactated Ringer's and Hextend Resuscitation on Hemodynamics and Coagulation following Femur Injury and Severe Hemorrhage in Pigs
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
Pagination or Media Count:
BACKGROUND This study compared coagulation function after resuscitation with Hextend and lactated Ringer s LR solution in pigs with tissue injury and hemorrhagic shock. METHODS Pigs were randomized into control n 7 each, LR, and Hextend groups. Femur fracture was induced using the captive bolt stunner at midshaft of the pigs left legs, followed by hemorrhage of 60 total blood volume and resuscitation with either Hextend equal to bled volume or LR to reach the same mean arterial pressure. Pigs in the control group were not bled or resuscitated. Hemodynamics was monitored hourly for 6 hours. Blood samples were taken at baseline BL, after hemorrhage, 15 minutes, 3 hours, and 6 hours after resuscitation for blood and coagulation measurements. RESULTS Mean arterial pressure decreased to 50 of BL by the 60 hemorrhage but returned to near BL within 1 hour after LR or Hextend resuscitation. Heart rate was increased from 91 - 4 beats per minute to 214 - 20 beats per minute by hemorrhage and decreased after resuscitation but remained elevated above BL in both groups. Resuscitation with Hextend 42 mLkg or LR 118 - 3 mLkg reduced hematocrit, total protein, fibrinogen, and platelet counts, with greater decreases shown in the Hextend group. Clot strength was lower but returned to BL by 3 hours in the LR group, whereas it remained reduced for the 6-hour period after Hextend. The overall clotting capacity after LR was decreased after hemorrhage and resuscitation but returned to BL by 3 hours, whereas it remained low after Hextend for the 6-hour experiment period. CONCLUSION After traumatic hemorrhage, coagulation function was restored within 6 hours with LR resuscitation but not with Hextend.
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