Accession Number:

ADA615424

Title:

Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells

Descriptive Note:

Final rept. 1 Mar 2011-31 Aug 2014

Corporate Author:

GENEVA FOUNDATION TACOMA WA

Personal Author(s):

Report Date:

2014-11-01

Pagination or Media Count:

82.0

Abstract:

Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE