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Bisphosphonates in the Prevention of Post-Traumatic Osteoarthritis

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Annual rept. 1 Jul 2013-30 Jun 2014

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The following accomplishments with regard to the Aim 2 tasks partnering-PI C. Prices responsibility for grant PR120788P1 are noted. The animal surgery model DMM that constitutes the majority of the proposed research has been brought into the laboratory and we have completed 30 of the projected surgeries and specimen collections with minimal complications. Currently, the entire cohort of Baseline, Age-Matched, and DMM-surgery controls have been collected and are undergoing analytical quantification. The cohort of Sham-surgery controls is currently in progress. Furthermore, we have established in-house the processing, embedding, microtomy, and staining techniques, as well as the micro-CT scanning and analysis techniques required for the studies in task 1. Specimen cohorts that have already been collected are undergoing these protocols and analytical procedures as proposed. Studies involving the treatment arm groups of the project will begin shortly and we foresee no difficulties in the performance of this portion of the project. Initial data regarding the natural time-course of joint structure and cellular biology changes in the DMM mouse model are being prepared for submission to the ORS Annual Meeting. The current data constitutes critical control data for the i.a. ZA treatment cohorts proposed in this study.

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  • Medicine and Medical Research
  • Pharmacology

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