Accession Number:

ADA615117

Title:

Development of Practical and Rapid Field-Based Therapies for SCI

Descriptive Note:

Final rept. 30 Sep 2010-29 Sep 2013

Corporate Author:

CALIFORNIA UNIV SAN DIEGO LA JOLLA

Personal Author(s):

Report Date:

2014-02-01

Pagination or Media Count:

8.0

Abstract:

We have designed a set of experiments to test candidate therapies for spinal cord injury SCI that could be applied in the battlefield and other acute traumatic settings. Specifically, we aim to optimize a combinatorial treatment to augment behavioral recovery following severe spinal cord contusion. These strategies include 1 augmentation of the intrinsic growth state of an injured neuron by elevating cyclic AMP levels, and 2 modifying the extrinsic toxicinhibitory spinal cord environment by transplantation of cells secreting growth factors.

Subject Categories:

  • Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE