Development of Practical and Rapid Field-Based Therapies for SCI
Final rept. 30 Sep 2010-29 Sep 2013
CALIFORNIA UNIV SAN DIEGO LA JOLLA
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We have designed a set of experiments to test candidate therapies for spinal cord injury SCI that could be applied in the battlefield and other acute traumatic settings. Specifically, we aim to optimize a combinatorial treatment to augment behavioral recovery following severe spinal cord contusion. These strategies include 1 augmentation of the intrinsic growth state of an injured neuron by elevating cyclic AMP levels, and 2 modifying the extrinsic toxicinhibitory spinal cord environment by transplantation of cells secreting growth factors.
- Anatomy and Physiology
- Medicine and Medical Research