Gamma Delta T-Cells Regulate Wound Myeloid Cell Activity After Burn
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
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The morbidity and mortality associated with major burn can, in part, be attributed to various derangements of the immune system and inflammatory response that contributes to the subsequent development of systemic inflammatory response syndrome and multiple organ failure 1, 2. Nonetheless, inflammation has a beneficial role at times and, in particular, plays a major role in the complex process of wound repair. The regulation and propagation of inflammatory responses are highly regulated and involve multiple immune cell types i.e., T cells, macrophages, neutrophils. Numerous studies have implicated macrophages and other myeloid cells in postburn immune dysfunction 2-5. In general, these studies have supported a concept of hyperactivation of the myeloid cell with elevated release of various pro- inflammatory mediators. Nonetheless, these studies have primarily focused on circulating leukocytes or cells from primary immune organs, such as the spleen. Although studies have examined wound macrophage function and phenotypes 6-8, detailed analysis of the myeloid cells at the healing burn wound site have not been conducted. Recent findings with a wound sponge model suggest an important role for myeloid cells and gamma delta T cells in the burn wound-healing response 9, 10. Nonetheless, this model system did not look at the cells directly infiltrating the burn wound.
- Anatomy and Physiology
- Medicine and Medical Research