Accession Number:

ADA614765

Title:

Characterization of Skin Allograft Use in Thermal Injury

Descriptive Note:

Journal article

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Report Date:

2013-01-01

Pagination or Media Count:

8.0

Abstract:

This study provides objective data on the practice of allograft usage in severely burned patients. Furthermore, gaps in our knowledge are identified, and areas for further research are delineated. Using an institutional review board-approved protocol, active duty military patients injured while deployed in support of overseas contingency operations and treated at our burn center between March 2003 and December 2010 were identified. Their electronic medical records were reviewed for allograft use, TBSA burned, injury severity score, anatomic distribution of burns, operative burden, length of stay, transfusions, and outcome. Among 844 patients, 112 13.3 received allograft and 732 86.7 did not. The amount of allograft used per patient varied and was not normally distributed median, 23.5 interquartile range, 69.5. Patients received allograft skin an average of 12.75 times during their admission. Allografted patients sustained severe burns , 53.8 TBSA most were transfused 71.2 and grafted frequently, averaging every 7.45 days. Most commonly, allograft was placed on the extremities 66.5 followed by the trunk 44.2 however, the vast majority of allografted patients also had concomitant burns of the head 91.1 and hands 87.5. All-cause mortality among the allografted patients was 19.1. In conclusion, allograft is commonly used in the surgical treatment of severe burns. Although there are no anatomic limitations to allograft placement, there are distinct patterns of use. Given the role of allograft in the acute management of large burns, there is need for further investigation of its effect on mortality, morbidity, and antigenicity.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE