Fibrinogen Concentrate in Dilutional Coagulopathy: a Dose Study in Pigs
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
Pagination or Media Count:
Dilutional coagulopathy can be reversed with fibrinogen concentrate. Effects of different fibrinogen dosages on clot function are not defined high doses my increase the risk of thromboemboembolism. This study investigated the effect of six fibrinogen dosages on coagulation profile and blood loss in coagulopathic pigs. Forty-two pigs underwent a 60 hemodilution HD with hydroxyethystarch HES1300.4. After a standardized bone injury, animals randomly received 37.5, 75, 150, 300, 450 or 600 mgkg fibrinogen FGTW, LFB or 500 ml of saline. Four hours later, a standardized liver injury was performed. Animals were then observed for two hours or until death. Blood loss was measured after death Hemodynamic and coagulation parameters thromboelastometry were measured at baseline BL, after HD, 15 1, 2, 4 hours after fibrinogen administration and 2 hours after liver injury or right before the animals death.
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