High-Throughput Functional Validation of Progression Drivers in Lung Adenocarcinoma
Final rept. 1 Sep 2012-31 Aug 2014
BAYLOR COLL OF MEDICINE HOUSTON TX
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The primary objective of our Early Investigator Synergistic Idea Award is to establish a driver prioritization pipeline to functionally evaluate lung cancer genomics data to identify somatic driver aberrations, which beyond the handful of well-characterized genes like oncogenic KRAS, contribute to lung cancer progression. As outlined in our Annual Report, we have successfully constructed the necessary gene libraries for the screens outlined in our proposal, optimized and completed the proposed in vitro cell invasion screens and will complete full analysis on the in vivo metastasis screens by the time of our Final Report. These combined efforts have revealed several robust drivers of cell invasion and in vivo metastasis that will be 1 developed into hypothesis-driven projects funded by additional award mechanisms and 2 fuel target biology studies aimed at translating our findings into new patient therapies. We have also made a number of key technical advanced over the course of this project that will have a sustained impact on screening of lung cancer genomics data beyond the life of this particular award.
- Medicine and Medical Research