Accession Number:

ADA614501

Title:

A Comprehensive Tool and Analytical Pathway for Differential Molecular Profiling and Biomarker Discovery

Descriptive Note:

Final rept. Jan 2010-Sep 2014

Corporate Author:

AIR FORCE RESEARCH LAB WRIGHT-PATTERSON AFB OH HUMAN PERFORMANCE WING (711TH) HUMAN EFFECTIVENESS DIRECTORATE/HUMAN CENTERED ISR DIV

Personal Author(s):

• Grigsby, Claude C.

Report Date:

2014-10-20

Pagination or Media Count:

114.0

Abstract:

Comprehensive and reproducible sample collection techniques were developed concomitantly with the informatics tool and used in multiple, independent studies for the validation and further development of generated software tools and approaches. Data from a dose-response study examining an organ specific environmental toxicant exposure was analyzed using the prototype software tool for discovery of LCMS based metabolomic biomarkers.

Descriptors:

• *COMPUTER PROGRAMS
• *MOLECULES
• *SAMPLING
• *SIGNS AND SYMPTOMS
• GAS CHROMATOGRAPHY
• GENE EXPRESSION
• LIQUID CHROMATOGRAPHY
• MASS SPECTROMETRY
• METABOLISM
• MODIFICATION
• ORGANIC COMPOUNDS
• PROTEOMICS

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE