Accession Number:

ADA614489

Title:

Activity of Imipenem against Klebsiella pneumoniae Biofilms In Vitro and In Vivo

Descriptive Note:

Journal article

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX ARMY DENTAL AND TRAUMA RESEARCH DETACHMENT

Personal Author(s):

• Chen, Ping
• Seth, Akhil K.
• Abercrombie, Johnathan J.
• Mustoe, Thomas A.
• Leung, Kai P.

Report Date:

2014-02-01

Pagination or Media Count:

7.0

Abstract:

Encapsulated Klebsiella pneumoniae has emerged as one of the most clinically relevant and more frequently encountered opportunistic pathogens in combat wounds as the result of nosocomial infection. In this report, we show that imipenem displayed potent activity against established K. pneumoniae biofilms under both static and flow conditions in vitro. Using a rabbit ear model, we also demonstrated that imipenem was highly effective against preformed K. pneumoniae biofilms in wounds.

Descriptors:

• *ANTIBIOTICS
• *KLEBSIELLA PNEUMONIAE
• *WOUNDS AND INJURIES
• IN VITRO ANALYSIS
• IN VIVO ANALYSIS

Subject Categories:

• Medicine and Medical Research
• Microbiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE