Accession Number:

ADA614460

Title:

Echo-Planar Imaging-Based, J-Resolved Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer

Descriptive Note:

Annual rept. 30 Sep 2013-29 Sep 2014

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

Report Date:

2014-10-01

Pagination or Media Count:

37.0

Abstract:

Purpose 1 To implement an echo-planar imaging EPI-based 2D J-resolved spectroscopy on a 3T MRIMRS scanner2 To evaluate the multi-voxel 2D J-resolved echo-planar spectroscopic imaging EP-JRESI in malignant PCa patients, benign prostatic hyperplasia BPH patients and healthy prostates. 3 To develop and further optimize the ProFit algorithm to postprocess the multi-dimensional MRS data from different prostate pathologies. Scope Improved cancer detection specificity in differentiating malignant from benign prostate cancer will be achieved using a novel four-dimensional 4D EP-JRESI. Improved spectroscopic imaging techniques will enable unambiguous detection of metabolites and the lipids in situ, which could potentially complement the existing diagnostic modalities commonly used in prostate cancer. Progress and Major Findings After successful implementation of the 4D EP-JRESI sequence on a 3T MRI scanner, the 4D EP-JRESI data were recorded in several patients and healthy males during the first two years. Eleven more male subjects 6 patients and 5 healthy were investigated using endorectal as well as external MRI coils and the findings are reproducible with that obtained in the past years. A manuscript was peer-reviewed by a leading MR journal during the last year.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE