P11, A Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress
Final rept. 15 Sep 2008-14 Sep 2014
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
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This is our final report for the project P11, A Biomarker for Memory Retrieval A Possible Role in Traumatic Stress. We carried out all of the experiments based on the proposed research design. We tested memory retrieval performance with wild type and p11 knockout mice, which developed and bred by us with since JAX. There were two sets of results control data and experimental data sets. The controls were wild-type and p11 knockout mice, and pharmacological controls i.e., mice received saline injection and stress controls yoked foot shock. The experimental groups were wild-type or p11 knockout mice, which received pharmacological treatment corticosterone injection and foot shock exposure. We found that the latency to find platform was shorter in p11 knockout mice than that in wild type mice during training day 1-3, although the latency for both wild and knock-out was not different on the final day of training or probe test. We also found that corticosterone resulted in significant decreases in the time spent in quadrant and number of island crossing in both p11 knockout and wiled type control. Our data indicate that p11 knock-out enhances memory retrieval and corticosterone induced-impairment of memory retrieval is independent of the p11 expression.
- Medicine and Medical Research