Effect of Antimicrobial Peptide KSL-W on Human Gingival Tissue and C. albicans Growth, Transition and Secreted Aspartyl Proteinase (SAPS) 2, 4, 5 and 6 Expressions
Annual rept. 1 Apr 2012-31 Mar 2013
LAVAL UNIV QUEBEC
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The antifungal armamentarium for the treatment of systemic fungal infections has increased in recent years. Although very helpful to controleliminate fungal infections, the available antifungal drugs do have some limitations such as antifungal drug resistance. As an example, azole resistance is an issue in patients with chronic mucocutaneous candidiasis caused by C. albicans in the context of HIV-infected individuals with recurrent oropharyngeal and esophageal candidiasis. A similar trend in vaginal isolates of C. albicans has been seen in women prone to recurrent vaginal candidiasis exposed to long-term fluconazole Bulik et al., 2009,Shahid and Sobel, 2009. In the latter scenario fortunately relatively rare to date therapeutic options available for oral management of fluconazole-reduced susceptibility C. albicans are few, resulting in the inconvenient use of long-term topical imidazoles. These facts have generated greater interest in the development of new antifungal drugs using various synthetic and naturally occurring antimicrobial molecules. Natural antimicrobial peptides, such as defensins produced by epithelial cells, showed a broad range of antibacterial activity and could play a role in preventing microbial infectionsDecanis et al., 2009,Zaslof, 2002. These antimicrobial peptides generally exhibit selective toxicity for microorganisms and show fewer propensities to induce microbial resistance.
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