Molecular Profiles for Lung Cancer Pathogenesis and Detection in U.S. Veterans
Final rept. 20 Sep 2010-19 Sep 2014
VANDERBILT UNIV NASHVILLE TN
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Uncertainty about the clinical behavior of a premalignant lesion can lead to either inappropriate inaction or inappropriate aggressive treatment, either of which can result in harm to the patient. The main goals of this DOD grant and program was to shed light on the molecular mechanisms of airway field cancerization and development of premalignant lesions. During this grant, we investigated and began to understand multiple mechanisms that lead to field of cancerization, including genomic aberrations and microRNA and gene expression changes. We have characterized the transcriptomic architecture of the adjacent airway field cancerization in early-stage NSCLC and validated the expression of a novel field cancerization markers in airways and tumors. Furthermore, we understood how the molecular field of injury evolves spatiotemporally and identified gradient profiles in the localized field cancerization that highly embody the nearby lung tumors. We identified field of injurycancerization biomarkers that are specific to NSCLC vs benign disease, inform of NSCLC pathogenesis and can detect lung cancer when assessed in minimally invasive sites in the lung.
- Medicine and Medical Research