Accession Number:

ADA614409

Title:

Role of Extracellular miR-122 in Breast Cancer Metastasis

Descriptive Note:

Annual rept. 15 Jan 2014-14 Jan 2014

Corporate Author:

CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA

Personal Author(s):

Report Date:

2015-02-01

Pagination or Media Count:

13.0

Abstract:

Reprogrammed glucose metabolism due to increased glycolysis and glucose uptake is a hallmark of cancer. We show that cancer cells can suppress glucose metabolism in endothelial, lung fibroblasts, and brain astrocyte niche cells through secreting exosomal miR-122, a miRNA whose level in the circulation predicts metastasis of breast cancer. MiR-122 suppresses glucose uptake and metabolism primarily through down-regulating the glycolytic enzyme pyruvate kinase M2 PKM2. Our results demonstrate that cancer cells are capable of influencing how niche cells metabolize glucose through exosome secretion of miR-122 and the consequent down-regulation of glucose metabolic enzymes in niche cells leading to reduced glucose utilization.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE