Role of Extracellular miR-122 in Breast Cancer Metastasis
Annual rept. 15 Jan 2014-14 Jan 2014
CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA
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Reprogrammed glucose metabolism due to increased glycolysis and glucose uptake is a hallmark of cancer. We show that cancer cells can suppress glucose metabolism in endothelial, lung fibroblasts, and brain astrocyte niche cells through secreting exosomal miR-122, a miRNA whose level in the circulation predicts metastasis of breast cancer. MiR-122 suppresses glucose uptake and metabolism primarily through down-regulating the glycolytic enzyme pyruvate kinase M2 PKM2. Our results demonstrate that cancer cells are capable of influencing how niche cells metabolize glucose through exosome secretion of miR-122 and the consequent down-regulation of glucose metabolic enzymes in niche cells leading to reduced glucose utilization.
- Anatomy and Physiology
- Medicine and Medical Research