Accession Number:

ADA614357

Title:

Acetaminophen and Meloxicam Inhibit Platelet Aggregation and Coagulation in Blood Samples from Humans

Descriptive Note:

Journal article

Corporate Author:

ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Report Date:

2014-01-01

Pagination or Media Count:

8.0

Abstract:

Acetaminophen Ace and meloxicam Mel are the two types of analgesic and antipyretic medications. This study investigated the dose responses of acetaminophen and meloxicam on platelet aggregation and coagulation function in human blood samples. Blood samples were collected from six healthy humans and processed to make platelet-adjusted 100T103 cellsml blood samples. Acetaminophen Tylenol, Q-PAP, 100 mgml was added at the doses of 0mgml control, 214mgml the standard dose, 1T, 4T, 8T, 10T, 12T, 16T, and 20T. Similarly, meloxicam Metacam, 5 mgml was added at doses of 0mgml control, 2.85mgml the standard dose, 1T, 4T, 8T, 10T, 12T, 16T, and 20T. Fifteen minutes after the addition of acetaminophen andor meloxicam, platelet aggregation was stimulated with collagen 2mgml or arachidonic acid 0.5 mmoll and assessed using a Chrono-Log 700 aggregometer. Coagulation function was assessed by prothrombin time PT, activated partial thromboplastin time aPTT, and using Rotem thrombelastogram. A robust inhibition by acetaminophen andor meloxicam was observed in arachidonic acid-stimulated platelet aggregation starting at 1T dose. Collagen-stimulated platelet aggregation was inhibited by ACE starting at 1T 78W10 of control, and by meloxicam starting at 4T 72W5 of control, both P0.05. The inhibitions by acetaminophen and meloxicam combined were similar to those by acetaminophen or meloxicam. aPTT was prolonged by meloxicam starting at 4T. No changes were observed in PT or any of Rotem measurements by acetaminophen andor meloxicam. Acetaminophen and meloxicam compromised platelet aggregation and aPTT. Further effort is warranted to characterize the effects of acetaminophen and meloxicam on bleeding in vivo.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE