Operation Brain Trauma Therapy
Annual rept. 30 Sep 2012-29 Sep 2013
PITTSBURGH UNIV PA
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Operation Brain Trauma Therapy OBTT is a multi-center pre-clinical drug screening consortium testing therapies in multiple animal models of traumatic brain injury TBI with the goal of identifying the best therapies for clinical trials. OBTT is also evaluating serum biomarkers of TBI across its models. Screening of therapies is carried out at three sites using three distinct rat models, i.e., parasagittal fluid percussion injury FPI, University of Miami, controlled cortical impact CCI, University of Pittsburgh, and penetrating ballistic-like brain injury PBBI, WRAIR. The serum biomarkers GFAP and UCH-L1 are being serially assessed in all models Banyan. Biomarker development is also ongoing in a large animal micropig FPI model Virginia Commonwealth University with parallel studies. The most promising drug will be tested in the micropig model to advance a therapy up the phylogenic scale. OBTT s work is ongoing as it completes year 3 of operation. OBTT is currently screening its 6th drug, has studied 600 rats, and assessed 1000 biomarker samples.
- Medicine and Medical Research