Accession Number:

ADA614229

Title:

Operation Brain Trauma Therapy

Descriptive Note:

Annual rept. 30 Sep 2013-29 Sep 2014

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

• Kochanek, Patrick M.

Report Date:

2014-10-01

Pagination or Media Count:

34.0

Abstract:

Operation Brain Trauma Therapy OBTT is a multi-center pre-clinical drug screening consortium testing therapies in multiple animal models of traumatic brain injury TBI with the goal of identifying the best therapies for clinical trials. OBTT is also evaluating serum biomarkers of TBI across its models. Screening of therapies is carried out at three sites using three distinct rat models, i.e., parasagittal fluid percussion injury FPI, University of Miami, controlled cortical impact CCI, University of Pittsburgh, and penetrating ballistic-like brain injury PBBI, WRAIR. The serum biomarkers GFAP and UCH-L1 are being serially assessed in all models Banyan. Biomarker development is also ongoing in a large animal micropig FPI model Virginia Commonwealth University with parallel studies. The most promising drug will be tested in the micropig model to advance a therapy up the phylogenic scale. OBTT s work is ongoing as it completes year 3 of operation. OBTT is currently screening its 6th drug, has studied 900 rats, and assessed 3000 biomarker samples.

Descriptors:

• *DRUGS
• *TRAUMATIC BRAIN INJURIES
• SIGNS AND SYMPTOMS
• THERAPY

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE