Accession Number:

ADA614132

Title:

Radiation-Induced Vaccination to Breast Cancer

Descriptive Note:

Annual rept. 30 Sep 2013-29 Sep 2014

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

Report Date:

2014-10-01

Pagination or Media Count:

14.0

Abstract:

The purpose of this study is to combine the TGFbeta neutralizing antibody, Fresolimumab, with Radiation Therapy RT to treat metastatic breast cancer. This is based on the rationale that RT can be limited to 1 or 2 lesions which in turn serve as antigenic reservoirs that drive abscopal effects. Patients receive either 1mg or 10mg of the anti-TGFbeta antibody.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Radiobiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE