7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities?
Annual rept. 30 Sep 2013-29 Sep 2014
VANDERBILT UNIV NASHVILLE TN
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We present the first annual report for this project. We have developed and deployed a quantitative MRI set of MRI scans at 7T in healthy volunteers and have developed an analysis pipeline for the quantification of macromolecular and metabolic indices reflective of demyelination and neurotransmitterprotein accumulation. All quantitative MRI methods deployed in humans were optimized and vetted via phantom work and simulation. We are happy to report initial findings that show excellent image quality and differences between the normal cohort and one MS patient. Additionally, we have developed, in conjunction with Dr. Newhouse, a neurocognition expert, an extensive neuropsychiatric battery for correlation studies in year 2. We have had excellent recruitment and retention and look forward to group comparisons in year 2.
- Anatomy and Physiology
- Medicine and Medical Research
- Physical Chemistry
- Atomic and Molecular Physics and Spectroscopy