Delivery of Nano-Tethered Therapies to Brain Metastases of Primary Breast Cancer Using a Cellular Trojan Horse
Annual rept. 15 Sep 2013-14 Sep 2014
RICE UNIV HOUSTON TX
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Our studies provide insight that aqueous solubility is one of the keys to success for nanoparticle enabled delivery. We note that almost all the small molecule tyrosine kinase inhibitors have poor aqueous solubility, which suggests that innovative formulations of these compounds will be required. Absorption of light by the skull and scatter of light by the brain parenchyma significantly reduce the dose of light that can be delivered to intracranial lesions. This has prompted us to develop work-arounds, which include utilizing multiple NIR sources and examining various beam profiles. Our future plans also include examining the loading and unloading of therapeutics that are known DNA intercalators and which are watersoluble. We will also examine the effect of mimicking the interstitial fluid composition in our lapatinib release experiments to determine if this mitigates some of the aqueous solubility challenge.
- Medicine and Medical Research