Accession Number:

ADA613874

Title:

The Contribution of Genotype to Heterotopic Ossification after Orthopaedic Trauma

Descriptive Note:

Annual rept. 15 May 2009-14 Apr 2010

Corporate Author:

VANDERBILT UNIV MEDICAL CENTER NASHVILLE TN

Personal Author(s):

Report Date:

2010-05-01

Pagination or Media Count:

10.0

Abstract:

We build on our earlier findings of three potential contributing genetic factors ADRB2, TLR4, CFHin the development of heterotopic ossification HO. Demographic and environmental data for 1313 patients were compiled in addition to radiographic findings of HO in the same cohort. Statistical analyses were performed to determine associations between ISS, head AIS, ICU days, days on ventilator support, race and gender on the development of HO. In addition, we have begun extraction on another 1161 patient specimens to add genetic data to the 2426 specimens already extracted in our repository. Along with the 36 SNPs we planned to investigate in our original proposal, we will add an additional 60 SNPs to include more pathways recently identified in the literature and that are associated with our initial findings.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE