Association of Cytokine Candidate Genes with Severity of Pain and Co-Occurring Symptoms in Breast Cancer Patients Receiving Chemotherapy
Final rept. 15 Sep 2011-2 Dec 2014
CALIFORNIA UNIV SAN FRANCISCO
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This project is a cross-sectional observational study of 391 patients receiving chemotherapy for breast cancer. The purpose of this project was to identify demographic, clinical, and psychological characteristics associated with the severity of pain and co-occurring symptoms i.e., fatigue, sleep disturbance, depressive symptoms, as well as to identify genetic variations in cytokine genes associated with the experience of these symptoms, Latent class profile analysis was used to identify subgroups of patients with distinct experiences with this symptom cluster i.e., pain, fatigue, sleep disturbance, depressive symptoms. Three subgroups were identified and differences in demographic and clinical characteristics, psychological symptoms, and quality of life among the subgroups were evaluated. Quality control procedures, genotype scoring, and analyses for ancestry informative markers were conducted, with final statistical analyses for genetic data underway. The identification of factors that contribute to variability in the experience of pain and associated symptoms may help to identify high-risk patients and inform intervention efforts.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research