Effects of Acute Oral 5-aminotetrazole (5-AT) Exposure to Rats (Rattus norvegicus)
Final rept. Aug-Sep 2013
ARMY PUBLIC HEALTH COMMAND ABERDEEN PROVING GROUND MD ARMY INST OF PUBLIC HEALTH
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5-AT is a potential replacement for perchlorate in pyrotechnic devices. The objectives of this study were to determine the oral acute and subacute toxicity of 5-AT in the rat. 5-AT was not acutely toxic and no mortalities were observed at the limit dose of 2000 milligrams per kilogram mgkg body weight in the acute test. There were no clinical signs of toxicity or morbidity observed in the subacute 14-day study up to 623 mgkg-day-- the highest dose tested for both male and female rats. Without adverse effects, determination of the LOAEL and derivation of the BMD were not possible. The NOAEL was 623 mgkg-day, the highest dose used in the subacute exposure test. The acute and subacute tests indicated that 5-AT has low toxicity over a short expose time frame. 5-A Tis a less tox ic compound than perchlorate and it should be pursued as a replacement. Considering that 5-AT is also used in the synthesis of two other munition components, 5-nitrotetrazole 5-NT and copper I 5-nitrotetrazolate DBX-1, a subchronic 90 day oral study is recommended.
- Anatomy and Physiology
- Medicine and Medical Research