Accession Number:

ADA613289

Title:

Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing

Descriptive Note:

Annual rept. 22 Aug 2013-21 Aug 2014

Corporate Author:

INDIANA UNIV INDIANAPOLIS

Personal Author(s):

Report Date:

2014-09-01

Pagination or Media Count:

84.0

Abstract:

This is a progress report Year 3 for the development of a novel therapeutic drug salubrinal and guanabenz for skeletal diseases, focusing on potential treatment of osteoporosis and bone fracture. The study in the third year was focused on the subtasks in Tasks 3, 4, and 5, using animal models and in vitro cell cultures. In vivo data supported efficacy of salubrinal and guanabenz on strengthening bone in bone necrosis Task 3 and bone fracture Task 4. In vitro data showed genome-wide mRNA microRNA expression patterns in response to salubrinal and guanabenz, and they indicated novel signaling molecules involved in the responses to salubrinal and guanabenz. In Task 5, a clinical trial of guanabenz is being planned at Indiana University for cancer patients with bone metastasis who suffer from severe bone loss. The study in the fourth year will be conducted focusing on Task 4 bone fracture using local administration of the proposed agents, together with integration of in vitroin vivo data for a clinical trial at Indiana University.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE