A Label-Free and Chemical-Selective Microendoscope to Enhance Prostate Cancer Surgical Outcomes
Annual rept. 30 Sep 2013-29 Sep 2014
METHODIST HOSPITAL HOUSTON TX
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Identification of cavernous nerves CNs and prostate surgical margins are two critical determinants for the outcome of radical prostatectomy. Currently there is no real time cancer diagnosis technology available when doing the prostate cancer tumor removal surgery. Our group is developing a miniaturized Coherent Anti-Stokes Raman scattering CARS system to identify malignant prostate tissue and tumor margin without optical labels or contrast agents. We have successfully finished the design of a high precision, label-free microendoscope based on the integration of CARS, microelectromechanical systems MEMS, and four-wave mixing FWM noise suppression technologies. The 14 mm transversal diameter of the round-shaped CARS microendoscope probe paves the way towards future handheld multimodal CARS imaging for real time minimally invasive prostate cancer diagnosis. We have examined the feasibility of multimodal prostate imaging with CARS and second harmonic generation SHG using patient specimen and mouse models. The next step will be in vivo imaging and algorithm development with the all-fiber microendoscope system. This work presents a significant milestone in CARS endoscopy development using micro optics and MEMS mirror which greatly reduce the size of CARS endoscopy while keeping high imaging definition quality.
- Medicine and Medical Research
- Medical Facilities, Equipment and Supplies
- Fiber Optics and Integrated Optics