Accession Number:

ADA612875

Title:

MMB-4 Inhibition of Aceylcholinesterase Is Similar across Species

Descriptive Note:

Technical rept. Jun 2013-Jul 2014

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Report Date:

2014-11-01

Pagination or Media Count:

10.0

Abstract:

MMB-4, an oxime that can reactivate acetylcholinesterase AChE after inhibition by some nerve agents, is currently in advanced development for potential human use as a replacement for the currently fielded oxime 2-PAM. It has long been known that while certain oximes can be therapeutically effective against OP intoxication at appropriate doses, they can also act as reversible inhibitors of AChE at higher doses. This study was designed to test the hypothesis that the unexpected toxicity of MMB-4 in rabbits is due to increased sensitivity of rabbit AChE to inhibition by MMB-4 compared with AChE from other species.

Subject Categories:

  • Biochemistry
  • Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE