MMB-4 Inhibition of Aceylcholinesterase Is Similar across Species
Technical rept. Jun 2013-Jul 2014
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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MMB-4, an oxime that can reactivate acetylcholinesterase AChE after inhibition by some nerve agents, is currently in advanced development for potential human use as a replacement for the currently fielded oxime 2-PAM. It has long been known that while certain oximes can be therapeutically effective against OP intoxication at appropriate doses, they can also act as reversible inhibitors of AChE at higher doses. This study was designed to test the hypothesis that the unexpected toxicity of MMB-4 in rabbits is due to increased sensitivity of rabbit AChE to inhibition by MMB-4 compared with AChE from other species.
- Medicine and Medical Research