Microvesicle Production After Trauma and its Clinical Impact on Veno-thrombolism
Annual rept. 27 Sep 2011-26 Sep 2012
MAYO CLINIC ROCHESTER MN
Pagination or Media Count:
Polytrauma is most often caused from explosive devices and accounts for about 65 percent of injuries to our military personnel. The patients who have polytrauma are at increased risk of developing either bleeding andor a clot in their veins which cause a life-threatening event known as venous thromboembolism VTE. We began enrollment of patients into the study on 2 February 2011. As of 1 October 2012, we have successfully enrolled and collected blood samples on 684 patients and 64 healthy volunteers. We have thus far analyzed plasma samples of over 230 patients and 64 volunteers. In our preliminary analysis of thrombin generation and procoagulant microvesicle analysis, we have observed that thrombin generation is accelerated early after traumatic injury and there are greater numbers of procoagulant microvesicles noted after traumatic injury relative to healthy volunteers.
- Anatomy and Physiology
- Medicine and Medical Research