Accession Number:

ADA612873

Title:

Microvesicle Production After Trauma and its Clinical Impact on Veno-thrombolism

Descriptive Note:

Annual rept. 27 Sep 2011-26 Sep 2012

Corporate Author:

MAYO CLINIC ROCHESTER MN

Personal Author(s):

Report Date:

2012-10-01

Pagination or Media Count:

13.0

Abstract:

Polytrauma is most often caused from explosive devices and accounts for about 65 percent of injuries to our military personnel. The patients who have polytrauma are at increased risk of developing either bleeding andor a clot in their veins which cause a life-threatening event known as venous thromboembolism VTE. We began enrollment of patients into the study on 2 February 2011. As of 1 October 2012, we have successfully enrolled and collected blood samples on 684 patients and 64 healthy volunteers. We have thus far analyzed plasma samples of over 230 patients and 64 volunteers. In our preliminary analysis of thrombin generation and procoagulant microvesicle analysis, we have observed that thrombin generation is accelerated early after traumatic injury and there are greater numbers of procoagulant microvesicles noted after traumatic injury relative to healthy volunteers.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE