Neural Correlates of Restricted, Repetitive Behaviors in Autism Spectrum Disorders
Annual rept. 6 Sep 2012-5 Sep 2013
MASSACHUSETTS GENERAL HOSPITAL BOSTON
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During the period of 09062012-09052013, we enrolled an additional 34 participants with ASD and 10 control participants. Of these, one healthy control and six participants with ASD were unable to complete the study. To date, we were able to acquire phenotyping data, ASD characterization if applicable, anatomical images, DTI images, fMRI images, and genotyping data for a total of 43 participants with ASD and 24 control participants. Their phenotyping data and ASD characterization have all been updated onto REDCap, a free, secure, web-based application designed to support data capture for research studies. We also reconstructed structural MRI data, unpacked bold and DTI data, performed functional to structural registration, checked registration, performed quality control both during the scanning session and through PACE analysis, ran functional connectivity preprocessing and created seed files for future seed-specific functional connectivity analysis. Due to significant effects of motion on functional and diffusion MRI data, we are taking extra measures to perform quality control on our data including the use of Artifact Detection Tools ART on our functional data and DTIPrep on our diffusion data. These tools allow us to automatically and manually remove time-series or gradients that have been affected by motion.
- Medicine and Medical Research