Abnormal Vestibulo-Ocular Reflexes in Autism: A Potential Endophenotype
Final rept. 15 May 2010-14 May 2014
FLORIDA UNIV GAINESVILLE
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The overarching objective of this study was to characterize abnormalities of vestibulo-ocular reflexes in Autism Spectrum Disorder ASD. Specific Aim 1 To characterize aberrations in horizontal VOR post-rotary nystagmus without optokinetic feedback using a velocity step test. We hypothesize that in ASD vertical eye movement intrusions during horizontal nystagmus will occur more frequently than normal, will be time-locked to horizontal nystagmus, and will differ from voluntary saccades. Specific Aim 2 To apply a linear systems analysis based method for testing horizontal VOR without optokinetic feedback using sinusoidal oscillation tests. We hypothesize that gain and phase lag of horizontal VOR will differ in children with ASD compared to controls. Specific Aim 3 To characterize in ASD vertical VOR and torsional VOR, both without optokinetic feedback, using velocity step tests.
- Anatomy and Physiology
- Medicine and Medical Research