Simulation of Blast Loading on an Ultrastructurally-based Computational Model of the Ocular Lens
Annual rept. 30 Sep 2012-29 Sep 2013
COLORADO UNIV AT BOULDER
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Research progress over the past year focused on imaging of lens fiber cell structure using confocal laser scanning microscopy CLSM, and type IV collagen structure using cryo-electron microscopy and tomography cryo-EM and ET. The CLSM promises to generate good structural identification of lens fiber cells, while the cryo-EM and ET have not yet positively identified type IV collagen structure of the lens capsule. The collaboration with Dr. Vernerey of CU Boulder on large deformation Lagrangian-Eulerian computational modeling of the lens will be extended to three-dimensions 3D and ultra-structurally based modeling of capsule and fiber cells. Such modeling could be extended to the whole eye globe, given the ease of using Eulerian-based methods in large deformation computational mechanics and solidfluid interaction. Tracking interfaces is the challenge, and such details are being investigated as part of the research.
- Anatomy and Physiology
- Operations Research
- Fluid Mechanics