Accession Number:

ADA612855

Title:

Simulation of Blast Loading on an Ultrastructurally-based Computational Model of the Ocular Lens

Descriptive Note:

Annual rept. 30 Sep 2012-29 Sep 2013

Corporate Author:

COLORADO UNIV AT BOULDER

Personal Author(s):

Report Date:

2013-10-01

Pagination or Media Count:

12.0

Abstract:

Research progress over the past year focused on imaging of lens fiber cell structure using confocal laser scanning microscopy CLSM, and type IV collagen structure using cryo-electron microscopy and tomography cryo-EM and ET. The CLSM promises to generate good structural identification of lens fiber cells, while the cryo-EM and ET have not yet positively identified type IV collagen structure of the lens capsule. The collaboration with Dr. Vernerey of CU Boulder on large deformation Lagrangian-Eulerian computational modeling of the lens will be extended to three-dimensions 3D and ultra-structurally based modeling of capsule and fiber cells. Such modeling could be extended to the whole eye globe, given the ease of using Eulerian-based methods in large deformation computational mechanics and solidfluid interaction. Tracking interfaces is the challenge, and such details are being investigated as part of the research.

Subject Categories:

  • Anatomy and Physiology
  • Operations Research
  • Explosions
  • Fluid Mechanics
  • Mechanics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE