Neurocognitive and Biomarker Evaluation of Combination mTBI from Blast Overpressure and Traumatic Stress
Final rept. 1 Sep 2010-31 Aug 2014
GENEVA FOUNDATION TACOMA WA
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Mild traumatic brain injury mTBI and post-traumatic stress disorder PTSD are major medical issues for the Warfighter. The current project is designed to evaluate the impact of mild traumatic brain injury using blast overpressure and the processes involved in traumatic stress using a predator exposure procedure and a conditioned fear procedure in a rodent model. The studies evaluate these insults alone and in combination to specifically address the question of whether mTBI can exacerbate the effects of psychological stress. Additionally, following the insults, a molecular biological evaluation is performed based upon the discovery of biomarkers that have been shown to be correlated with other forms of TBI. Thus, the project aims to systematically assess the combined effects of blast overpressure, traumatic stress and learned stress responses in rodents with the aim of understanding how these forces may interact to impact behavior as well as evaluating their outcome on known biomarkers involved in TBI and stress response system activation.
- Anatomy and Physiology
- Medicine and Medical Research