In Vivo 18-FDG/18-Choline-Mediated Cerenkov Radiation Energy Transfer (CRET) Multiplexed Optical Imaging for Human Prostate Carcinoma Detection and Staging
Annual rept. 16 Sep 2013-15 Sep 2014
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Prostate cancer is treatable in its earliest stages, although treatment options for advanced forms are limited. Therefore, more sensitive means of early prostate cancer detection and new prostate cancer therapies are needed. Two novel biomarkers are proposed to associate with prostate cancer progression the Thomsen-Friedenreich disaccharide TF antigen and the ErbB-2ErbB-3 heterodimer ErbB23. The objective of this proposal is to examine whether internal illumination via 18F-fluorocholine Cerenkov radiation energy transfer CRET coupled with TF- and ErbB23- molecularly targeted near-infrared NIR QDs can be used to detect prostate cancer. We have shown that ErbB2ErbB3 dimerization is hergulin mediated and upregulated in castrated mice bearing MDAPCa- 2b human prostate cancer xenografts. We have selected peptides from bacteriophage display libraries that target TF and ErbB2ErbB3. The peptides have been attached to QDs and are being used to detect prostate cancer cell lines that express TF, ErbB2ErbB3 and various stages of cancer.
- Medicine and Medical Research
- Non-electrical Energy Conversion
- Quantum Theory and Relativity