Targeting Alpha5 Beta1 Integrin to Prevent Metastatic Breast Cancer Cell Invasion: PhScN Target Site Definition and Plasma Stability
Annual rept. 1 Sep 2013-31 Aug 2014
MICHIGAN UNIV ANN ARBOR
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We proposed to test PHSCN and PhScN derivatives with modifications of the N or C termini, andor cysteine side chain to determine the initial spatial constraints of the binding pocket of the ligand to its target site. This will aid in the selection of crosslinking agents, modifications, tag additions and strategies for determination of the target sites performed in Aim 2 and lay the foundation for determining the structure-activity relationships SARS of these inhibitors with the target.
- Medicine and Medical Research