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A Clinically Realistic Large Animal Model of Intra-Articular Fracture

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Final rept. 15 Sept 2010-14 Sept 2014

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The primary objective of this project is to develop a novel large animal survival model of intra-articular fracture IAF in which all major pathophysiological attributes corresponding to human injuries are realistically replicated, and in which post-traumatic osteoarthritis PTOA predictably develops. This final report summarizes all project activities. Initial work included development of hardware to reliably induce a highly repeatable fracture of the Yucatan minipig hock and development of a definitive post-operative treatment protocol. These methods were used in a series of 22 animals to document the natural history of the fractured and repaired joint over a 12 week survival period, focusing on limb loading, joint inflammatory response, bone healing, and cartilage degeneration. After the natural history was established, a short-term study was performed for the purpose of demonstrating that a promising biological treatment could be meaningfully investigated in this new model. In that work an antioxidantanti-inflammatory cocktail was given immediately after fracture and 24 hours later. Specific measures of whole joint and chondrocyte health were made using direct biological measures and histology. Over the course of this project, the model was fully developed, the natural history including joint degeneration was documented, and the model was shown to be an appropriate vehicle for investigation of promising treatments to prevent PTOA.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

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