Overcoming the Practical Barriers to Spinal Cord Cell Transplantation for ALS
Annual rept. 30 Sep 2013-29 Sep 2014
EMORY UNIV ATLANTA GA
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This grant has provided so far critical data on tolerance and toxicity of cell dosing and numbers of permissible spinal cord injections. Rigorous experiments in Aim 1 of our grant have demonstrated that, even though the porcine spinal cord seems to tolerate escalating numbers and volumes of injections, the severity of acute transient morbidity should not be neglected. Moreover, escalating numbers and volumes of injections seem to be associated with lack of accuracy and reflux. At the same time, little is understood about the appropriate immunosuppressive therapy for spinal cord stem cell transplant recipients. In our ongoing human trial, aggressive immunosuppressant therapy has formed the single biggest source for adverse events. Aim 2 will help us to optimize immunosuppression, preventing needless complications.
- Anatomy and Physiology
- Medicine and Medical Research