Accession Number:

ADA612720

Title:

Overcoming the Practical Barriers to Spinal Cord Cell Transplantation for ALS

Descriptive Note:

Annual rept. 30 Sep 2013-29 Sep 2014

Corporate Author:

EMORY UNIV ATLANTA GA

Personal Author(s):

Report Date:

2014-10-01

Pagination or Media Count:

20.0

Abstract:

This grant has provided so far critical data on tolerance and toxicity of cell dosing and numbers of permissible spinal cord injections. Rigorous experiments in Aim 1 of our grant have demonstrated that, even though the porcine spinal cord seems to tolerate escalating numbers and volumes of injections, the severity of acute transient morbidity should not be neglected. Moreover, escalating numbers and volumes of injections seem to be associated with lack of accuracy and reflux. At the same time, little is understood about the appropriate immunosuppressive therapy for spinal cord stem cell transplant recipients. In our ongoing human trial, aggressive immunosuppressant therapy has formed the single biggest source for adverse events. Aim 2 will help us to optimize immunosuppression, preventing needless complications.

Subject Categories:

  • Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE