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Studies of the Effects of Perfluorocarbon Emulsions on Platelet Number and Function in Models of Critical Battlefield Injury

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Annual rept. 15 December 2012- 14 December 2013, Phase 1

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Perfluorocarbon emulsions PFCs can treat traumatic injuries traumatic brain injury TBI, hemorrhagic shock and burns by enhanced delivery of oxygen. A class-based side effect of PFC day 2-5 after infusion in 30-50 may be thrombocytopenia TCYP. The mechanism is inadequately investigated but is caused by reduced production or enhanced clearance partial activation of platelets Plts. The United States Food and Drug Administration FDA requests investigation of the phenomenon to exclude Plt inflammatoryembolic safety risks. In phase one of the study, healthy juvenile sheep were used with a top load intravenous infusion of either PFC Oxygent, n7, Hespan n6, or na vesaline control n6. Venous blood was sampled before the treatment baseline and at 0 minute, 3 and 24 hours, 4 and 7 days after treatment. Blood samples were measured for coagulation parameters including platelet count, fibrinogen, thrombin, CD62p etc. The results showed that the sheep s platelet count and fibrinogen level were not significantly reduced after PFC top-loaded for the 7 survival days. Platelet activation assay CD62p also showed no increase compared with control groups na ve Hespan. Morphologically, platelet activation was not significantly increased compared with baseline or controls. Therefore, treatment with Oxygent in healthy sheep did not cause massive or severe coagulopathy.

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  • Medicine and Medical Research

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