Early Identification of Molecular Predictors of Heterotopic Ossification Following Extremity Blast Injury with a Biomarker Assay
Annual rept. 30 Sep 2013-29 Sep 2014
MEDICAL UNIV OF SOUTH CAROLINA CHARLESTON
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The purpose of this project is to identify predictive markers of heterotopic ossification in an established animal model that would forecast development of HO in humans soon after injury. Since relocation to MUSC, the PI has been fully engaged in securing suitable facilities and related institutional and state regulatory approvals to implement the animal blast model at MUSC. This was accomplished in July 2014, nearly 15 months after the PI s arrival on 1 April, 2013. Blast procedures have been completed on all 30 animals in the year 1 SOW they are now nearly 3 months postblast and are being survived and followed according to protocol with scheduled biopsies and routine radiographs to monitor progression of HO. Specimen samples have been obtained and are under analysis for identification of protein biomarkers. Year 2 SOW animal procedures will begin on schedule in the fifth quarter of the award.
- Anatomy and Physiology
- Medicine and Medical Research