Accession Number:

ADA612607

Title:

Targeting Androgen Receptor by Lysosomal Degradation in Prostate Cancer

Descriptive Note:

Annual rept. 1 Sep 2013-31 Aug 2014

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO

Personal Author(s):

Report Date:

2014-09-01

Pagination or Media Count:

18.0

Abstract:

Androgen receptor AR plays a critical role in the progression of prostate cancer. This project is directed towards testing the feasibility of targeting AR for lysosomal degradation. We have demonstrated that AR can indeed be targeted for degradation by stimulating the TFEB lysosome degradation pathway either by increasing the TFEB levels or by activating TFEB using mTORC1 kinase inhibitor, torin 1. Additionally, we determined that the same approach can be used to target the EWS-Fli-1 oncoprotein for degradation.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE