Accession Number:

ADA612595

Title:

Mechanisms of Mitochondrial Defects in Gulf War Syndrome

Descriptive Note:

Annual rept. 15 Jul 2012-14 Jul 2013

Corporate Author:

GEORGIA STATE UNIV ATLANTA

Personal Author(s):

Report Date:

2013-10-01

Pagination or Media Count:

12.0

Abstract:

Gulf War syndrome GWS is associated with increased incidences of amyotrophic lateral sclerosis, pain syndromes, muscle complaints that include fatigue and myalgias, as well as other neurological symptoms. Approximately 100,000 individuals have medical complaints consistent with GWS. Clinical manifestations are similar to those identified in Chronic Fatigue Syndrome CFS. Mitochondrial defects are identified pathologically, metabolically, and genetically in some patients with CFS. GWS has significant evidence for mitochondrial dysfunction with abnormalities in exercise physiology, abnormalities in mitochondrial morphology, biochemical defects in mitochondrial function, abnormalities in free radical generation affecting mitochondrial integrity, gene expression in genes affecting mitochondrial function, and mtDNA mutations inherited, somatic, and sporadic during embryogenesis. Gene expression abnormalities in CFS show abnormalities in genes that are related to mitochondrial function. Hence, investigation of mitochondrial dysfunction in GWS is a priority.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE