Accession Number:

ADA612594

Title:

AltitudeOmics: The Basic Biology of Human Acclimatization to High Altitude

Descriptive Note:

Final rept. 1 Jan 2011-30 Jun 2013

Corporate Author:

COLORADO UNIV AT DENVER

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

129.0

Abstract:

For the last 12 months we have been working on data analysis and manuscript preparation. The first 6 papers from this study have been published, and another 6 are in preparation. The overview physiology paper was accepted last week at PLOS ONE, and the others have been accepted in major physiology journals. The next batch of papers will be from the OMICS portion of the study. We hired a new bioinformatics postdoc in October, and he has hit the ground running with comprehensive analyses of the OMICS dataset. The gene expression paper will be complete in another 3-4 weeks, and shortly after that the metabolomics and epigenetics data will be ready for publication. By the end of 2014 all major papers form the study will have been published. So far the project is from our perspective a complete success with identification of new physiological aspects of acclimatization, and first-ever insights into the underlying OMICS mechanisms. We are now looking for one additional year of funding to explore new analyses and integration that is possible because of the high quality of this dataset, and that could lead to even more comprehensive, big picture views of the process of human acclimatization to hypoxia at high altitude.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE