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Prediction of Susceptibility to Acute Mountain Sickness Using Hypoxia-Induced Intrapulmonary Arteriovenous Shunt and Intracardiac Shunt Fractions

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Annual rept. 1 Oct 2012-30 Sep 2013

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We have spent the first year getting IRB approval and meeting with other experts in high altitude physiology and medicine to ensure that our research approach is solid. The following organizations have approved our protocol a Sacred Heart Medical Center IRB, the review board for Oregon Heart and Vascular Institute b Oregon Public Health and Safety OPHS and the University of Oregon Radiation Safety Committee c The State of Oregon d The University of Oregon IRB e The Department of Defense IRB. Robert Roach, Ph.D., Director of the Altitude Center at the University of Colorado School of Medicine provided us with an enormous amount of insight and assistance in ensuring that we will succeed in our aims. The hyperbaric chamber was set up and potential subjects have begun to be recruited. Two subjects have completed part of the protocol. The data thus far support our hypothesis that individuals who are susceptible to Acute Mountain Sickness AMS will have significantly greater amounts of shunt in hypoxia andor have an intracardiac shunt such as a PFO and thus a greater degree of arterial hypoxemia than individuals who are not AMS susceptible.

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  • Medicine and Medical Research

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