Accession Number:

ADA612549

Title:

Hibernation-Based Therapy to Improve Survival of Severe Blood Loss

Descriptive Note:

Annual rept. 1 Oct 2011-30 Sep 2012

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS

Personal Author(s):

Report Date:

2012-10-01

Pagination or Media Count:

20.0

Abstract:

The purpose of these experiments was to address the dose response relationship for the toxicity of the drug product via I.V. or I.O. infusion and to assess the effectiveness of the drug to maintain adequate dosing concentrations when given either I.V. or I.O. We found no toxic effects from the drug when administered I.V. or I.O. as reported in pathology. Adequate dosing concentrations were maintained in animals receiving a high-dose of BHBM. However, I.O. administration seemed to be more effective than the I.V. administration. When BHBM was administered at full dose, I.V. administration was statistically more effective at maintaining the desired BHBM concentrations when compared to the full dose BHBM I.O. administration.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE