Hibernation-Based Therapy to Improve Survival of Severe Blood Loss
Annual rept. 1 Oct 2011-30 Sep 2012
MINNESOTA UNIV MINNEAPOLIS
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The purpose of these experiments was to address the dose response relationship for the toxicity of the drug product via I.V. or I.O. infusion and to assess the effectiveness of the drug to maintain adequate dosing concentrations when given either I.V. or I.O. We found no toxic effects from the drug when administered I.V. or I.O. as reported in pathology. Adequate dosing concentrations were maintained in animals receiving a high-dose of BHBM. However, I.O. administration seemed to be more effective than the I.V. administration. When BHBM was administered at full dose, I.V. administration was statistically more effective at maintaining the desired BHBM concentrations when compared to the full dose BHBM I.O. administration.
- Medicine and Medical Research